021-51111890
购物车（0）
sales@molnova.cn
BMS-470539 dihydrochloride
CAS No. 2341796-82-3
BMS-470539 dihydrochloride ( —— )
产品货号. M32812 CAS No. 2341796-82-3
BMS-470539 dihydrochloride 是一种高效的选择性黑皮质素 1 受体 (MC-1 R) 激动剂，IC50 为 120 nM，EC50 为 28 nM。BMS-470539 dihydrochloride 不激活 MC-3R，并且对 MC-4R 和 MC-5R 的激活活性非常弱。BMS-470539 dihydrochloride 具有强效的抗炎特性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥672 | 有现货 |
|
| 5MG | ￥993 | 有现货 |
|
| 10MG | ￥1599 | 有现货 |
|
| 25MG | ￥3558 | 有现货 |
|
| 50MG | ￥5826 | 有现货 |
|
| 100MG | ￥9027 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称BMS-470539 dihydrochloride
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述BMS-470539 dihydrochloride 是一种高效的选择性黑皮质素 1 受体 (MC-1 R) 激动剂，IC50 为 120 nM，EC50 为 28 nM。BMS-470539 dihydrochloride 不激活 MC-3R，并且对 MC-4R 和 MC-5R 的激活活性非常弱。BMS-470539 dihydrochloride 具有强效的抗炎特性。
-
产品描述BMS-470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC-1R) agonist with an IC50 of 120 nM, an EC50 of 28 nM. BMS-470539 dihydrochloride does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R. BMS-470539 dihydrochloride has potently anti-inflammatory properties.
-
体外实验——
-
体内实验Animal Model:Wild-type (WT) and MC1 receptor recessive e/e mice induced with ischaemia-reperfusion Dosage:2.05 mg/kg, 6.16 mg/kg and 18.47 mg/kg Administration:Intravenous injection; for 125 minutes Result:Inhibited cell adhesion and emigration with no effect on cell rolling. Inhibited tissue expression of both CXCL1 and CCL2.
-
同义词——
-
通路GPCR/G Protein
-
靶点Melanocortin Receptor
-
受体Melanocortin Receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number2341796-82-3
-
分子量632.62
-
分子式C32H43Cl2N5O4
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO 中的溶解度 : ≥ 125 mg/mL (197.59 mM ) H2O 中的溶解度
-
SMILESCCCC(C1(C2=CC=CC=C2)CCN(CC1)C([C@H](NC([C@@H](N)CC3=CN=CN3C)=O)CC4=CC=C(C=C4)OC)=O)=O.Cl.Cl
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Herpin TF, et al. Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties. J Med Chem. 2003 Mar 27;46(7):1123-6.?
产品手册
关联产品
-
ACTH 11-24 acetate(4...
ACTH 11-24 acetate(4237-93-8 free base) (Adrenocorticotropic Hormone (11-24) acetate) is a fragment of adrenocorticotrophin, induces cortisol release. ACTH (11-24) has been identified as a competitive antagonist of ACTH (1-39) and ACTH (1-10) in isolated adrenal cells.
-
PF-00446687 hydrochl...
PF-00446687 盐酸盐 (PF-446687) 是一种有效的选择性 melanocortin-4 受体 (MC4R) 激动剂，EC50 为 12 nM。
-
γ1-MSH
Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.
